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In vivo , apigenin reduces the secretion of pro-inflammatory factors (IL-1, IL-6, and TNF-), reduces the expression of the DCs costimulatory molecules CXCR4 and MHCII, and reduces the number of Langerhans cells

Kvandov and colleagues investigated the function of PPAR, a nuclear receptor implicated in the regulation of lipid metabolism, emphasizing its importance in cardiovascular disorders linked to type 2 diabetes (57)