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The cascade runs pituitary GH liver-derived IGF-1 tissue effect, and IGF-1 is what drives protein synthesis, satellite-cell activation (muscle repair), lipolysis in adipose tissue, collagen synthesis, and bone remodeling

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In this context, chronic hypoxia treatment has shown some promise in various preclinical models of Friedreichs ataxia, indicating a key role for oxygen in the pathogenesis 173,174