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Fourth, predictive biomarkers capable of reliably stratifying patients for immunotherapy and targeted treatments remain suboptimal, contributing to treatment variability and overtreatment in many cases (329)

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This reduction in intracellular GSH concentrations, combined with diminished ATP production, has been linked to increased vulnerability of dopaminergic neurons in PD, as observed in both in vitro and in vivo studies (Sian et al., 1994)

Morris JF, Omer S, Davies E, Wang E, John C, Afzal T et al (2006)