glutathione peroxidase 1a Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities Validated Applications Glutathione peroxidase-1 inhibits transcription of

These mechanistic insights point to the SNARE complex as a vulnerable target of Pb neurotoxicity and warrant further research into how Pb affects its structural and regulatory components in glutamatergic neurons

References Chen W, Zheng R, Zeng H, Zhang S

Ngounou WetieAGWormwoodKLCharetteLRyanJPWoodsAGDarieCC

Most positive trial data comes from clinical populations (NAFLD, Parkinson's, chronic disease states) where baseline GSH is pathologically low

High-resolution single-cell (sc) assays, including single-nucleus (sn) assays for RNA-seq and assay for transposase-accessible chromatin with sequencing (ATAC-seq) were performed (described in a recent manuscript 9 ), along with methylation analyses 10